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. Author manuscript; available in PMC: 2022 Jul 14.
Published in final edited form as: Chem Rev. 2021 Jun 15;121(13):7957–8094. doi: 10.1021/acs.chemrev.1c00138

Figure 3.

Figure 3.

Minimalistic outlines of β-lactam hydrolysis mechanisms by SBLs (a) and MBLs (b). B1 is a general base activating the nucleophilic Ser residue in SBLs, and B2 is a general base involved in the deacylation step of SBL-mediated hydrolysis. The specific residues involved in the mechanism are discussed in the text.