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. Author manuscript; available in PMC: 2022 Jul 14.
Published in final edited form as: Chem Rev. 2021 Jun 15;121(13):7957–8094. doi: 10.1021/acs.chemrev.1c00138

Figure 31.

Figure 31.

Angle determined by the loop L3 and the plane of the active site of NDM-1 (PDB 3SPU, green), and L3IMP (PDB 6C6I, cyan) and L3Pro (PDB 6CAC, yellow) mutants.337 Angles between Zn1, Cα of Ser69 and Cα of Gly63 are as follows: L3IMP, 68°; NDM-1, 88°; and L3Pro, 110°. L3IMP corresponds to NDM-1 in which the L3 loop (residues 57 to 68) was replaced by the one from IMP-1; L3Pro is a mutant of NDM-1 with a Pro inserted after Ala68.