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. Author manuscript; available in PMC: 2022 Jul 14.
Published in final edited form as: Chem Rev. 2021 Jun 15;121(13):7957–8094. doi: 10.1021/acs.chemrev.1c00138

Figure 5.

Figure 5.

a) Structural comparison of the global fold of the transpeptidase domain of a PBP enzyme (PBP2a – PDB 3ZG0) and SBLs from classes A (KPC-2 – PDB 20V5), C (PDC-3 – PDB 4GZB) and D (OXA-10 – PDB 1K55), and a class B enzyme, i.e., an MBL (NDM-1 – PDB 4EYL). The Ω-loop region in SBLs are highlighted in yellow. b) Active sites of class A, C and D SBLs, with key catalytic residues displayed as sticks.