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. Author manuscript; available in PMC: 2022 Jul 14.
Published in final edited form as: Chem Rev. 2021 Jun 15;121(13):7957–8094. doi: 10.1021/acs.chemrev.1c00138

Figure 53.

Figure 53.

a) Thiol-based inhibitors. b) Model of meropenem bound to NDM-1 (base PDB 3SPU). c – e) Crystal complexes of 17:IMP-1382 (c, PDB 1DD6), D-22:IMP-1706 (d, PDB 4C1G), and 24:NDM-1707 (e, PDB 6ZYP). Zn(II) ions are shown as grey spheres, protein residues are shown as white sticks (green sticks for residues involved in hydrophobic interactions with the ligand), while the bound ligands are shown as colored sticks and water molecules are shown as red spheres. Protein-ligand interactions are shown as dashed lines.