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a) Phosphonate-based inhibitors. b) Crystal complex of 26:IMP-1732 (PDB 5HH4). c) Crystal complex of 27:NDM-1733 (PDB 6D1D). Zn(II) ions are shown as grey spheres, protein residues are shown as white sticks (green sticks for residues involved in hydrophobic interactions with the ligand), while the bound ligands are shown as colored sticks. Protein-ligand interactions are shown as dashed lines.
