a) Boronate-based inhibitors. b-e) Crystal complexes of 29:VIM-2736 (b, PDB 6SP7), 29:NDM-1737 (c, PDB 6RMF), 30:NDM-1738 (d, PDB 6V1M) and 31:BcII631 (e, PDB 5FQB). Zn(II) ions are shown as grey spheres, protein residues are shown as white sticks, while the bound ligands are shown as colored sticks and water molecules are shown as red spheres. Protein-ligand interactions are shown as dashed lines.