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a) Inhibitors that covalently bind to the Cys ligand. b) Inhibitors that covalently bind to Lys224. c) Crystal complex of 36:IMP-1800 (PDB 1VGN) d) Crystal complex of 37:NDM-1801 (PDB 6OVZ). Zn(II) ions are shown as grey spheres, protein residues are shown as white sticks, while the bound ligands are shown as colored sticks. Protein-ligand interactions are shown as dashed lines.
