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. Author manuscript; available in PMC: 2022 Jul 14.
Published in final edited form as: Chem Rev. 2021 Jun 15;121(13):7957–8094. doi: 10.1021/acs.chemrev.1c00138

Figure 60.

Figure 60.

a) Structure of inhibitors leading to metal replacement in MBLs. b) Metal coordination sphere of NDM-1 bound to Bi(III)825 (PDB 5XP9). c) Metal coordination sphere of NDM-1 bound to Au(I) ions826 (PDB 6LHE). Bi(III) and Au(I) ions are shown as purple and gold spheres, respectively, while protein residues are shown as sticks and water molecules are shown as red spheres. Ligand-metal interactions are shown as dashed lines.