Table 4.
Proposed subdivisions of MBL subclasses B1 and B3 according to Berglund et al.221 The main phyla from which MBLs were isolated and representative enzymes with experimentally confirmed β-lactamase activity are indicated for each group.
| Group | Main phyla (in order of abundance) | Representative MBLs with experimentally confirmed activity |
|---|---|---|
| B1.1 | Proteobacteria | NDM, VIM, FIM |
| B1.2 | Proteobacteria | IMP, GIM, DIM, SIM, KHM, TMB |
| B1.3 | Bacteroidetes | CcrA |
| B1.4 | Bacteroidetes, Firmicutes | BcII, BlaB, JOHN, IND, MUS, TUS |
| B1.5 | Firmicutes, Proteobacteria, Spirochaetes | SPM, SPS |
| B3.1 | Proteobacteria, Firmicutes | CAR |
| B3.2 | Bacteroidetes, Proteobacteria, Acidobacteria | GOB, LRA3, PEDO-1, PEDO-2 |
| B3.3 | Acidobacteria, Proteobacteria | FEZ |
| B3.4a | Proteobacteria | BJP, CAU |
| B3.4b | Proteobacteria | L1 |
| B3.4c | Proteobacteria | AIM, SMB, LMB |
| B3.4d | Proteobacteria | THIN-B |
| B3.4e | Gemmatimonadetes | RM3, LRA2 |
| B3.4f | Proteobacteria | - |