Table 3.

Eligibility criteria

Criteria	Inclusion	Exclusion	Justification
Population	Human studies; elderly 70 years and older	Animal studies	Interested in clinical management
Language	English	Non-English studies	Reviewers only speak English
Time	No publication date restriction	NA	When the term #neoadjuvant is used in the literature
Study topic	Focus on the topic on the neoadjuvant treatment of locally advanced rectal cancer in elderly patients (70 years old and older).	Studies on stage 4 rectal cancer are excluded
Study design	Randomised or non-randomised cohort studies and systematic reviews with or without meta-analysis	Studies on colorectal cancer not including information on rectal cancer separately are not included