Table 4.

Data extraction framework

Bibliometrics	General study details	Other findings, limitations and quality issues
Authors Title Source Year of publication Institution/country of origin	Study design and methodology Population: Sample size Median age Gender Eastern Cooperative Oncology Group (ECOG) performance status Intervention: Types of neoadjuvant treatment, doses and duration Outcomes: Toxicities and grade of toxicities Pathological response and survivals	Other findings include dose reduction, treatment interruption, or delay in surgical resection due to treatment toxicities. Any reported limitations or quality issues with study methodologies