Figure 4.

Schematic of pathways related to lipid metabolism that were altered with butadiene exposure. Representative metabolites palmitate, oleate, palmitoyl-CoA, and oleoyl-CoA are plotted for the control and 2 ppm BD-exposed mice. The observed decreases in long-chain fatty acids and increases in fatty acyl-CoAs could be related to an upregulation of acyl-CoA synthetase long chain (ACSL), which has been previously shown to be upregulated in lung cancer. Metabolites in both the anabolic and catabolic pathways were differentially expressed in BD-exposed mice (see Table 1); *P<1×10⁻⁸