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. 2022 Apr 19;33(7-8):442–450. doi: 10.1089/hum.2021.243

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© Arpana Khatri et al., 2022; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License [CC-BY-NC] (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.

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Figure 1. — AAV seroprevalence and titer distribution among healthy donors in the United States. A NAb assay was used to evaluate seroprevalence and titers in 100 healthy donors within the United States against a panel of AAVs. (A) Adjusted seroprevalence among donors to multiple AAVs. Data are shown as seroprevalence percentage of NAb positive (grey; NAb titer ≥5) and negative (black; NAb titer <5) donors. (B) Titer distribution among all donors (unadjusted) against AAVs. (C) Seropositivity among all age groups. Donors were binned by age before calculating percent seropositivity within each age group. (D) Gender distribution of seropositive donors against AAVs. AAVs, adeno-associated viral vectors.