Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 30;22:175. doi: 10.1186/s12935-022-02600-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — Morphological characterization of cells from ascitic fluid and characterization of the primary ovarian carcinoma of the patient from whose ascitic fluid IPO43 was established. A Cells were collected by cytospins. Smears of cells stained with Giemsa show aggregates and isolated cells with irregular size, abundant cytoplasm and large nuclei, confirming the presence of malignant cells; Immunocytochemical characterization of cells was done using cytokeratin (CK) type I and II—AE1/AE3 (neoplastic cells are positive); Vimentin (neoplastic cells are predominately negative, macrophages and mesothelial cells were positive) and CA125 (neoplastic cells were positive), 100x. B Formalin fixed paraffin-embedded sections of patient tumor ovarian high grade serous carcinoma submitted to surgery and neoadjuvant chemotherapy (after 3^rd cycle) stained with hematoxylin and eosin (H&E) and immunohistochemical staining. Tumor cells show positive expression of epithelial marker Cam 5.2 (CK type II). Apical cell membrane staining for CA 125 in tumor cells. Cells exhibited nuclear positive expression for p53, p16, PAX8 and focally with WT1. Tumor cells were negative with vimentin (VIM), calretinin (CALRET) and HNF1β, 100x