FIG. 7.

Lymphocyte proliferation in acute CHIKV infection. CHIKV-infected macaques were administered BrdU at 2 days postinfection. Blood was collected serially after BrdU administration and stained with anti-CD3, CD4, CD8, CD20 and NKG2a, and BrdU antibodies for flow cytometric analysis. The data were compared to those form uninfected macaques. The cellular proliferation of CD4⁺ T cells (CD3⁺CD20⁻CD8⁻), CD8⁺ T cells (CD3⁺CD4^-CD8⁺), CD20⁺ B cells (CD3⁻CD20⁺), and NK cells (CD3⁻CD20⁻ CD8⁺NKG2a+) is shown in (A–D), respectively. The statistical differences between uninfected and CHIKV-infected groups were calculated by Mann–Whitney test.