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. 2022 May 2;22:178. doi: 10.1186/s12935-022-02577-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Knockdown of PICALM inhibits tumor growth in mice xenograft models. A The fluorescence intensity of tumors in the shCtrl group and shPICALM group was demonstrated. B The volume of tumors in shCtrl group and shPICALM group was measured after post-injection. C The average weight of tumors in shCtrl group and shPICALM group was measured. D Images of mice and tumors in shCtrl group and shPICALM group. E Tumor tissues in shCtrl group and shPICALM group were examined for Ki67 staining by IHC. The data was presented as the mean ± SD (n = 3). *P < 0.05