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. 2022 May 2;22:178. doi: 10.1186/s12935-022-02577-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — PICALM promotes CRC progression through the ERK/MAPK signaling pathway. A The potential mechanism of PICALM in CRC cells was analyzed by KEGG enrichment analysis. The names of enrichment pathways are shown on the left axis. The abscissa is enrichment factor. The high enrichment factor indicates that the enrichment of different proteins in this pathway is significant. B The effects of PICALM overexpression and MAPK inhibitor treatment on HCT 116 and RKO cells proliferation were detected by cell counting experiment. C The effects of PICALM overexpression and MAPK inhibitor treatment on HCT 116 and RKO cells apoptotic using flow cytometry analysis based on Annexin V-APC staining. D The effect of PICALM on the expression of canonical components of the ERK/MAPK signaling pathway was further examined by western blot analysis. The representative images were selected from at least 3 independent experiments. The data was presented as the mean ± SD (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001