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Known inhibitors of T-type channels with analgesic properties. a Left: structure of the high affinity and selectivity T-type channel inhibitor Z944. Right: Z944 shown within the binding pocket of Cav3.1. Adapted with permission from Zhao et al. [16]. b Structures of commonly utilized T-type channel inhibitors, with varying degrees of affinity and selectivity. Many of these compounds mediate analgesia in preclinical pain models
