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. 2022 May 2;22:483. doi: 10.1186/s12885-022-09522-3

Table 3.

Summary of product caracteristics (SmPC) for 6-thioguanine

Genric name
(abbreviation)
6-thioguanine
(6TG)
ATC-code ATC-code L0JBB03
Name and formulation Oral suspension, 5 mg/ml

Adverse Reactions

(frequency)

Very common

(> 1/10)

Bone marrow failure, sinusoidal obstruction syndrome (SOS), hyperbilirubinemia, hepatomegaly, weight increase due to fluid retention and ascites, portal hypertension, splenomegaly, esophageal varices and thrombocytopenia, increased hepatic enzymes, increased blood alkaline phosphatase and gamma glutamyl transferase, jaundice, portal fibrosis, nodular regenerative hyperplasia, peliosis hepatis

Common

(> 1/100 to < 1/10)

Stomatitis, gastrointestinal disorder, SOS in short-term cyclical therapy, hyperuricemia, hyperuricosuria and urate nephopathy

Uncommon

(≥1/1000 to < 1/100)

Rare

(≥1/10,000 to < 1/1000)

Necrotising colitis, hepatic necrosis

Very rare

(< 1/10,000)

Unknown Photosensitivity

SmPC accessed at medicines.org.uk