Table 2.

Significant associations between urinary excretion of pesticide residues and the composition of the faecal microbiota evaluated using shotgun metagenomics and metabolomics. Statistical models were established with MaAsLin2, using the pesticide levels as predictors. The model coefficient value (effect size) and the standard error from the model are reported along the p-values and its False Discovery Rate (FDR). Associations with FDR < 0.2 for creatinine adjusted models are reported

Response	Predictor	effect size	stderr	pval	FDR
	METABOLOMICS
Br2CA	N-methylglutamate	−0.15	0.04	0.0009	0.12
	enterolactone	0.17	0.05	0.0011	0.13
	N-succinyl-isoleucine	−0.12	0.04	0.0012	0.13
	palmitoyl-ethanolamide	−0.18	0.05	0.0017	0.13
	N-methylalanine	−0.20	0.06	0.0019	0.13
	2-hydroxyglutarate	−0.16	0.05	0.0026	0.14
	N-acetyl-1-methylhistidine.	−0.18	0.06	0.0026	0.14
	enterodiol	0.19	0.06	0.0030	0.14
	N2-methylarginine	−0.07	0.02	0.0038	0.16
	piperidine	−0.15	0.05	0.0041	0.16
	stearoyl-ethanolamide	−0.21	0.08	0.0060	0.17
	2-oxo-1-pyrrolidinepropionate	−0.08	0.03	0.0061	0.17
	dihydroferulate	−0.12	0.04	0.0073	0.19
	1-palmitoyl-2-arachidonoyl-GPC	0.11	0.04	0.0076	0.19
Trans.Cl2CA	oleoyl.linoleoyl.glycerol	0.23	0.07	0.0013	0.15
	linoleoyl-linoleoyl-glycerol	0.23	0.07	0.0014	0.15
	4-hydroxybenzoate	−0.14	0.05	0.0020	0.15
	glycerol	0.25	0.08	0.0023	0.15
	1-oleoyl-GPC18	0.25	0.08	0.0031	0.19
	anacardic.acid	0.30	0.10	0.0034	0.19
3.PBA	arachidoylcarnitine	−0.25	0.07	0.0005	0.12
	carotenediol	−0.13	0.04	0.0006	0.12
	3-methylurate	0.18	0.05	0.0007	0.12
	allantoin	−0.27	0.08	0.0007	0.12
	erucoylcarnitine	−0.23	0.07	0.0008	0.12
	lysine	−0.11	0.04	0.0027	0.18
glyphosate	3.hydroxystearate	0.51	0.14	0.0003	0.19
	lactobacillic acid	0.25	0.07	0.0010	0.19
	stearate	0.25	0.07	0.0010	0.19
	phosphate	0.41	0.12	0.0011	0.19
	2-hydroxylignocerate.	0.33	0.10	0.0011	0.19
	pentadecanoate	0.24	0.07	0.0013	0.19
	3-carboxyadipate	0.27	0.08	0.0019	0.19
	saccharopine	0.34	0.11	0.0019	0.19
	METAGENOMICS
Br2CA	Faecalitalea cylindroides	0.06	0.0002	1.3E-30	1.6E-28
	Streptococcus_anginosus_group	0.11	0.03	0.003	0.19
DEP	Hungatella hathewayi	−0.03	7.3E-5	2.0E-33	9.5E-31
	Collinsella aerofaciens	−0.19	0.007	2.65E-08	4.2E-6
	Clostridium bolteae	0.04	0.01	0.002	0.19
PBA	Bacteroides eggerthii	0.16	0.01	3.9E-8	1.9E-5
	Clostridium symbiosum	0.13	0.02	6.9E-5	0.02
sumDEP	Hungatella hathewayi	−0.03	7.3E-5	2.2E-33	1.1E-31
	Collinsella aerofaciens	−0.18	0.007	2.7E-8	4.2E-6
	Clostridium bolteae	0.05	0.01	0.0009	0.07
	Enterorhabdus caecimuris	0.01	0.004	0.001	0.1
sumDMP	Clostridium citroniae	0.02	2.8E-5	3.8E-43	5.49E-41
	Veillonella dispar	0.002	3.9E-5	2.0E-22	2.2E-20
	Clostridium bolteae	0.08	0.002	0.001	0.07
	Clostridium innocuum	0.14	0.04	0.001	0.07
	Eubacterium siraeum	−0.13	0.04	0.004	0.16