Table 2.
Characteristics of the clinical studies included in the meta-analysis
| Study | Age (years) | High level education (%) | Stable relationship (%) | Depression (%) | Anxiety (%) | DM (%) | Hypertension (%) | Dyslipidemia (%) | PE definition | Acquired PE (%) | ED definition |
|---|---|---|---|---|---|---|---|---|---|---|---|
| El Sakka et al., 2003 [13] | 53.4 | 58.6 | 91.3 | – | – | 100 | – | – | Self-reported | 40 | IIEF-EFD |
| Basile Fasolo et al., 2005 [16] | 49.1 | 18.7 | 68.0 | – | – | 6.2 | 17.5 | 8.8 | DSM IV | 69.8 | Self-reported |
| Laumann et al., 2005 [17] | 55.5 | 31.2 | 83.9 | – | – | 10.9 | 22.4 | - | Self-reported | – | Self-reported |
| Porst et al., 2007 [18] | 41.6 | – | 80.5 | 14.2 | 15.5 | 7.8 | 22.2 | 20.1 | Self-reported | 34.6 | Self-reported |
| El Sakka et al., 2008 [19] | 56.8 | – | – | – | – | 78.2 | 34.5 | 36.9 | DSM IV | 100 | IIEF-EFD |
| Malavige et al., 2008 [20] | 55.6 | – | – | – | – | 100 | 41.5 | – | DSM IV | – | IIEF-5 |
| McMahon et al., 2009 [21] | 33.2 | – | 100 | – | – | – | – | – | ISSM | 0 | IIEF-5 |
| Liang et al., 2010 [22] | 33.8 | – | 100 | – | – | – | – | – | ISSM | – | IIEF-5 |
| Son et al., 2010 [23] | 35.5 | 66.5 | 70.2 | – | – | – | – | – | DSM IV | – | IIEF-EFD |
| Vakalopoulos et al., 2011 [24] | 29.8 | 72.6 | 29.6 | – | 32.8 | – | – | – | ISSM | 35 | Self-reported |
| Tang et al., 2011 [25] | 46.0 | – | 80.7 | 2.9 | 9.2 | 28.0 | 37.7 | 30.4 | PEDT | - | IIEF-5 |
| McMahon et al., 2012 [26] | 18–65 | 40 | 69.0 | 6.0 | 6.0 | 5.0 | 14.0 | 10.0 | PEDT | 49 | IIEF-5 |
| Shaeer et al., 2012 [27] | 35.2 | – | – | 20.6 | 7.1 | 6.6 | 8.1 | - | Self-reported | 43.7 | IIEF-5 |
| Shaeer et al., 2013 [28] | 52.4 | 37.6 | – | – | – | – | – | – | ISSM | – | IIEF-5 |
| Lee et al., 2013 [29] | – | 55.7 | 81.2 | 34.0 | 34.0 | 5.7 | 13.5 | 5.9 | PEDT | – | IIEF-5 |
| Gao et al., 2013 [38] and 2014 [41] | 33.7 | 33.7 | – | 4.6 | 12.0 | – | – | – | Self-reported | 18.8 | IIEF-5 |
| Maseroli et al., 2015 [32]* | 60.1 | 30.4 | 95.1 | 17.6 | – | 4.0 | 29.2 | 10.2 | Self-reported | – | Self-reported |
| Brody et al., 2015 | 42.8 | – | – | – | – | - | - | - | Self-reported | – | IIEF-5 |
| Mourikis et al., 2015 | 35.9 | – | 63.5 | – | – | – | – | – | DSM-IV | – | IIEF-15 |
| Salama et al., 2017* | 53.1 | – | – | – | – | – | – | – | PEDT | – | IIEF-5 |
| Salama et al., 2017** | 53.8 | – | – | – | – | – | – | – | PEDT | – | IIEF-5 |
| Zamree et al., 2018 | 46.3 | 67.7 | 100 | – | – | – | – | – | PEDT | 15.9 | IIEF-5 |
| Song et al., 2019 | – | 87.0 | 65.9 | 4.8 | – | 8.4 | 19.2 | – | Self-reported | – | IIEF-5 |
| Tsai et al., 2019 | 41.0 | 61.4 | 72.1 | 30.9 | 29.1 | 4.4 | 1.9 | – | PEDT | – | IIEF-5 |
| Zhang et al., 2019 | 33.2 | 56.3 | – | – | – | 3.1 | 5.6 | – | PEDT | – | IIEF-5 |
| Chin et al., 2021 | 53.4 | – | – | – | – | 26.8 | 31.7 | 49.6 | PEDT | 18 | IIEF-5 |
| Corona et al., 2021 | 58.9 | – | 92.2 | – | – | 6.4 | 27.9 | – | EMAS-SFQ | – | EMAS-SFQ |
| Mohamad et al., 2021 | 39.7 | – | 100 | – | – | 0 | – | – | PEDT | – | IIEF-EFD |
IIEF, International Index of Erectile Function; EFD, Erectile Function Domain; PEDT, Premature Ejaculation Diagnostic Tool; ISSM, International Society for Sexual Medicine; DSM-IV-TR, Diagnostic and Statistical Manual of Mental Disorders 4th Edition Text Revised; DM, diabetes mellitus, PE, premature ejaculation
* Florentine Centre of the European Male Aging Study was considered. * MetS, **no MetS