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. 2022 May 3;41:162. doi: 10.1186/s13046-022-02372-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — A Flow cytometric results of the cellular uptake capacity of HA/ZIF-8@Gem/D-1-MT NPs into K7M2 cells after the incubation at different time periods. Cellular uptake of different formulations into K7M2 cells after incubation for 4 h by flow cytometry (B) and inverted fluorescence microscope (C) (Scale bar = 200 μm). D Flow cytometric results of the cellular uptake capacity of HA/ZIF-8@Gem/D-1-MT NPs into MG63 cells after the incubation at different time periods. Cellular uptake of different formulations into MG63 cells after incubation for 4 h by flow cytometry E and inverted fluorescence microscope (F) (Scale bar = 200 μm). MTT assay to detect the cytotoxicity of K7M2 (G), MG63 (H), HOS (I), and MC3T3-E1 (J) incubated with HA/ZIF-8@Gem/D-1-MT NPs or others. Clone formation assay of K7M2 (K) and MG63 (L) incubated with HA/ZIF-8@Gem/D-1-MT NPs or others. Control, C; ZIF-8@Gem/D-1-MT/Ce6 NPs, Z(GMC); HA/ZIF-8@Gem/D-1-MT/Ce6 NPs; HZ(GMC). (n = 4, * P < 0.05, ** P < 0.01, and *** P < 0.001)