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. 2022 May 3;41:162. doi: 10.1186/s13046-022-02372-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — A Schematic illustration of the animal experimental model. B Bioluminescence images of tumor-bearing BALB/c mice at different time points after intravenous injection with Ce6, ZIF-8@Gem/D-1-MT/Ce6 NPs, and HA/ZIF-8@Gem/D-1-MT/Ce6 NPs. The body weight (C) and tumor volumes (D) of K7M2 OS-bearing mice with different treatments. (n = 4, *** P < 0.001). E OS tissues were obtained with BALB/c mice on day 21 after receiving different treatments. F Weights of isolated tumors and tumor inhibition ratio of K7M2 OS-bearing mice in different groups (n = 4, *** P < 0.001). G-I The percentage of M-MDSCs and G-MDSCs in tumor tissue (n = 3, *P < 0.05 and *** P < 0.001). J-L The percentage of Th cells and CTLs in tumor tissue (n = 3, *P < 0.05 and *** P < 0.001). Control, C; D-1-MT, M; Gem, G; ZIF-8@Gem/D-1-MT NPs, Z(GM); HA/ZIF-8@Gem/D-1-MT NPs, HZ(GM). ZIF-8@Gem/D-1-MT/Ce6 NPs, Z(GMC); HA/ZIF-8@Gem/D-1-MT/Ce6 NPs: HZ(GMC)