TABLE 1.
Activity of telithromycin against intracellular MAC strains
| Drug dose (μg/ml) | No. of CFU/ml of macrophage lysate at day 4a
|
||
|---|---|---|---|
| MAC 100 | MAC 101 | MAC 109 | |
| None | (9.8 ± 0.1) × 105 | (8.2 ± 0.2) × 105 | (8.1 ± 0.2) × 105 |
| 1 | (9.6 ± 0.1) × 105 | (7.9 ± 0.1) × 105 | (7.6 ± 0.1) × 105 |
| 2 | (9.0 ± 0.1) × 105 | (7.6 ± 0.3) × 105 | (6.3 ± 0.2) × 105 |
| 4 | (7.9 ± 0.1) × 105 | (6.6 ± 0.4) × 105 | (5.5 ± 0.2) × 105 |
| 8 | (5.9 ± 0.1) × 105 | (5.6 ± 0.1) × 105 | (3.6 ± 0.1) × 105b |
| 16 | (4.8 ± 0.2) × 105b | (4.5 ± 0.2) × 105b | (2.5 ± 0.1) × 105b |
| 32 | (2.6 ± 0.3) × 105b | (3.5 ± 0.1) × 105b | (1.9 ± 0.2) × 105b |
| 64 | (1.6 ± 0.1) × 105b | (3.0 ± 0.1) × 105b | (1.6 ± 0.3) × 105b |
| 128 | (6.5 ± 0.1) × 104bc | (2.6 ± 0.4) × 105b | (1.2 ± 0.4) × 105b |
a
The numbers of intracellular bacteria at time zero (after infection but before treatment) were as follows: MAC 100, (8.5 ± 0.2) × 104; MAC 101, (7.9 ± 0.3) × 104; MAC 109, (7.4 ± 0.2) × 104.
b
P < 0.5 compared with the value for controls at 4 days (bacteriostatic activity).
c
P < 0.5 compared with the baseline level at time zero (bactericidal activity).