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Telithromycin concentration in the blood of micea
| Time (h) | Concn in blood (μg/ml) for the following dose:
|
||
|---|---|---|---|
| 100 mg/kg | 200 mg/kg | 400 mg/kg | |
| 0.5 | 3.90 | 6.64 | 9.51 |
| 1 | 3.95 | 8.12 | 8.78 |
| 2 | 4.91 | 11.47 | 11.07 |
| 4 | 3.97 | 9.18 | 9.41 |
| 8 | 2.16 | 7.36 | 8.86 |
Three uninfected mice were given telithromycin orally for each time point and dose. Blood was obtained via the tail vein. Drug levels in tissue have been published previously (9).
