TABLE 3.
Incidence of telithromycin-resistant MAC and frequency of telithromycin resistance in splenic homogenates
| Treatment | No. of mice with resistant bacteria/total no. of mice tested
|
Frequency of resistancea
|
|||
|---|---|---|---|---|---|
| 8 wk | 12 wk | 0 wk | 8 wk | 12 wk | |
| Telithromycin | 12/20 | 6/16 | 0 | 9.0 × 10−7 | 7.4 × 10−6 |
| Control | 0/12 | 8/12 | 0 | 0 | 6.2 × 10−9 |
| P value | >0.05 | 0.01 | 0.01 | ||
a
Based on the number of bacteria per gram of tissue by plating spleen homogenate onto a 7H10 agar plate containing 128 μg of telithromycin per ml and compared with the number of bacteria per gram of tissue on plates without antibiotic. The telithromycin MICs for the resistant strains were 512 μg/ml or higher.