Table 2.

The MR estimates of the causal effect of central obesity on BMD

Central obesity traits	IVW method			MR-Egger			Weighted median
	Beta*	95% CI	P-value	Beta*	95% CI	P-value	Beta*	95% CI	P-value
WC	0.150	(0.073, 0.227)	1.3 × 10− 4	0.383	(0.190,0.575)	3 × 10–4	0.235	(0.184, 0.286)	1 × 10–7
WCadjBMI	− 0.005	(− 0.130, 0.119)	0.930	0.018	(− 0.497, 0.534)	0.944	− 0.062	(− 0.123,− 0.001)	0.046
HC	0.061	(− 0.019, 0.141)	0.133	0.397	(0.174, 0.621)	0.001	0.167	(0.109, 0.225)	1 × 10–7
HCadjBMI	− 0.135	(− 0.216, − 0.054)	0.001	− 0.076	(− 0.379, 0.226)	0.622	− 0.118	(− 0.173, − 0.063)	1 × 10–7
WHR	0.194	(0.062, 0.325)	0.004	0.491	(− 0.113, 1.096)	0.123	0.081	(− 0.009, 0.171)	0.077
WHRadjBMI	0.209	(0.046, 0.372)	0.012	1.040	(0.358, 1.721)	0.005	0.026	(− 0.040, 0.092)	0.438

^*Beta: a ratio of changes in standard deviations of BMD to that of central obesity traits