FIGURE 13.

Three EVOdFNCs (2, 3, and 7) start with intervals characterized by the modularized DMNneg patterning defined by SNAPdFNC State 3, a state that is more occupied by SZ patients. All three EVOdFNCs start with a DMNneg type of pattern, but each presents a different dynamic context. EVOdFNC 2 (top left) exhibits a high-contrast DMNneg pattern that dissolves into diffuse dysconnectivity. EVOdFNC 3 (top middle) presents a persistent, unvarying low-contrast DMNneg pattern. EVOdFNCs 2 and 3 have very similar temporal means (displayed below each EVOdFNC), with distinguishing characteristics requiring representation of their temporal evolution. Only EVOdFNC 3 has significant positive symptom effects. In EVOdFNC 7, the DMNneg pattern is part of a dynamic progression leading to AVSM-dominant hyperconnectivity. Although DMNneg patterning is significantly associated with SZ in time-blind SNAPdFNC analysis, EVOdFNC 7 not only has higher RI in HCs but also is sensitive to positive symptom levels in SZ patients.