Table 3.
Univariate and multivariate Cox proportional hazards analysis of the correlation between overall survival (OS) and MICAL-L2 expression levels
| Characteristics | Total(N) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
| T stage (T3&T4 vs T1&T2) | 452 | 2.962 (1.372–6.395) | 0.006 | 2.759 (0.842–9.047) | 0.094 |
| N stage (N1&N2 vs N0) | 453 | 2.519 (1.691–3.752) | < 0.001 | 1.346 (0.744–2.434) | 0.326 |
| M stage (M1 vs M0) | 396 | 4.327 (2.763–6.776) | < 0.001 | 3.179 (1.785–5.664) | < 0.001 |
| Age (> 65 vs < =65) | 453 | 1.649 (1.077–2.526) | 0.021 | 2.372 (1.400–4.018) | 0.001 |
| Gender (Male vs FeMale) | 453 | 1.118 (0.756–1.654) | 0.575 | ||
| History of colon polyps (YES vs NO) | 385 | 0.783 (0.466–1.313) | 0.354 | ||
| Lymphatic invasion (YES vs NO) | 410 | 2.315 (1.520–3.525) | < 0.001 | 1.436 (0.848–2.432) | 0.178 |
| MICALL2 (High vs Low) | 453 | 1.751 (1.174–2.612) | 0.006 | 1.703 (1.046–2.773) | 0.032 |