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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Drug Alcohol Depend. 2021 Jul 29;228:108923. doi: 10.1016/j.drugalcdep.2021.108923

Table 5.

Key Question 2. What are the effects of adjunctive interventions on other health-related outcomes?

# Authors
  • Study Type

  • Sample Size (by study arm)

  • F/U period

Intervention
Summary
Non-SUD Health-
related
Outcomes
Psychosocial
1 Chawarski et al. (2008)
  • RCT

  • 24 (12,12)

  • 12 weeks

Weekly, manual guided behavioral drug and HIV risk reduction counseling and abstinent contingent buprenorphine take-home doses + weekly SMM. TAU consisted of weekly SMM. Both groups reduced HIV risk behaviors from baseline (26 % vs 17 %, p = 0.9).
7 Tetrault et al. (2012)
  • RCT

  • 47 (22,25)

  • 12 weeks

EMM consisting of drug counseling and medication adherence focusing on ARV adherence. TAU was bi-weekly SMM. No difference between groups in detectable viral load (p = 0.84) or CD4 count (p = 0.45).
Complementary/Integrative
18 Price et al. (2020)
  • RCT

  • 10 (5,5)

  • 10 weeks

Weekly mindful awareness in body-oriented therapy sessions. TAU consisted of SMM. Intervention group showed improved interoceptive skills learned from baseline of 2.09 (SD = 0.96) to follow up score of 3.47 (SD = 0.33). TAU group showed no improvement over time.
19 Lander et al. (2018)
  • Prospective pilot study using quasi-experimental design with matched controls.

  • 26 (13,13)

  • 12 weeks

Weekly yoga paired with SMM. TAU consisted of SMM. Both groups attended weekly group therapy and community-based peer recovery groups. The treatment by follow-up time interaction was significant for perceived stress (p = 0.03) indicating that the intervention had a larger effect than TAU. No difference on opioid cravings or sleep variables.
Structural Barriers to Care
20 Cochran et al. (2018)
  • Single-arm repeated measures study.

  • 21

  • 10 weeks prenatal/4 weeks post-natal

Patient navigators utilizing strength-based case management and motivational interviewing help connect women to medical care and psychosocial services. Relative to baseline, participants reported decreased depression measured by PHQ (OR = 7.70, CI 2.4–25.1).

Acronyms: Confidence interval (CI), mindful awareness in body-oriented therapy (MABT), Standard medical management (SMM), Treatment as usual (TAU).