Association constant Ka valuesa of the chiral acceptor and 3-BARF pairs.
| Entry | XB acceptor | K a, M−1 |
|---|---|---|
| 1 | (R)-8 | 6.1 ± 0.7 |
| 2 | (S)-8 | 6.0 ± 0.8 |
| 3 | (R)-9 | 94 ± 7 |
| 4 | (S)-9 | 91 ± 5 |
Association constant Ka measured in CDCl3 at 298 K and determined by fitting the 1H NMR titration data to 1 : 1 binding isotherm of BindFit.15 The given Ka and standard error are the calculated mean values of two parallel experiments. Full details given in the ESI.