Table 3.

List of eRNAs involved in inflammatory effects in tumors.

Cancer	Affected cell	Enhancer or SE	eRNA	Regulated gene	Mechanism	Function	Reference
Pre-B ALL	Pre-B ALL cell GREAT	No	eRNA	ICOSLG, IRF4, MSA1	Down-regulate migration, proliferation and apoptosis gene	Promotes malignant progression	(151)
Pre-B ALL	Pre-B ALL cell	CD19+/CD20+ spectrum SE	eRNA	ETV6-RUNX1	Interference with B-cell signaling and adhesion signaling	Disrupt normal B lymphopoiesis	(152)
T ALL	Leukemia cell	ARID5B enhancer	ARIEL eRNA	ARID5B MYC	Recruition of intermediary complexes and Stable E-P rings	Involve in T-cell leukemia formation	(97)
KSHV-infected primary effusion lymphoma	TRExBCBL1 cell	MYC SE	MYC eRNA (e486, e507, e530)	MYC	Alteration of host epigenome status	Promote viral lysis and replication	(153)
Chronic granulocytic leukemi	Leukemia cell	Hmrhl enhancer	Hmrhl eRNA	phkb	No	Regulate positively phkb genes	(154)
MLL rearranged leukemia	MLL leukemia cells	Enhancer	SEELA eRNA	SERINC2	Promotion of histone recognition	Regulate tumor metabolism	(155)
Chronic myeloid leukemia	Leukemia cell	VEGFA157 enhancer	VEGFA157 eRNA	VEGFA	Selective splicing of target genes	Promote CML pathology	(156)
Gastric cancer	Gastric epithelium	BIRC3 enhancer	BIRC3 eRNA	BIRC3 cIAP2	Inhibition of caspase-3 activation	Enhance apoptosis resistance in gastric epithelial cells	(92, 94)
Colorectal cancer	CRC cell	Carcinogenic SE	eRNA	IL-20RA	Elevated expression of cell proliferation and immune evasion genes	Modulate carcinogenic and immune pathways	(157)