Table 3:
Major molecular genetic abnormalities in acute leukemia.
| Leukemia | Cytogenetic Abn | Molecular Genetic Abn | Prognostic significance |
|---|---|---|---|
| AML | t(8;21)(q22;q22) | ETO-AML1 fusion | Favorable |
| inv(16)(p13;q22) | MYH11-CBFβ fusion | Favorable | |
| t(16;16)(p13;q22) | MYH11-CBFβ fusion | Favorable | |
| t(15;17)(q22;q21) | PML-RARα fusion | Favorable | |
| t(6;9)(p23;q34) | DEK-CAN fusion | Intermediate | |
| t(11;q23) | Fusions involving MLL | Unfavorable | |
| t(9;11)(p22;q23) | MLL-AF9 fusion | Unfavorable | |
| ALL | t(9;22)(q34;q11) | BCR-ABL fusion | Unfavorable |
| t(12;21)cryptic | TEL-AML1 fusion | Favorable | |
| t(1;19)(q23;p13) | E2A-PBX fusion | Unfavorable | |
| t(11;q23) | Fusions involving MLL | Unfavorable | |
| t(4;11)(q21;q23) | MLL-AF4 fusion | Unfavorable |
Abn: Abnormality, ALL: Acute lymphoblastic leukemia, AML: Acute myeloid leukemia.