Table 4:
Major molecular genetic abnormalities in soft-tissue tumors*.
| Type of soft tissue tumor | Cytogenetic Abn | Molecular genetic Abn |
|---|---|---|
| 1. Rhabdomyosarcoma | ||
| Spindle cell | NA | NA |
| Embryonal /Botryoid | Gains of 2, 7, 8, 12, 13; losses of 1, 6, 9, 14, and 17 |
IGF2, GOK, PTCH
TP53 |
| Alveolar | t(2;13)(q35;q14); t(1;13)(p36;q14) |
PAX3-FKHR
PAX7-FKHR |
| 2A. Non-rhabdomyosarcoma-EWS family | ||
| EWS/PNET | t(11;22)(q24;q12) t(21;22)(q22;q12) t(7;22)(p22;q12) |
EWS-FLI-1
EWS-ERG EWS-ETV1 |
| DSRCT | t(11;22)(p13;q12) | EWS-WT1 |
| Clear cell sarcoma | t(12;22)(q13;q12) | EWS-ATF1 |
| Extraskeletal myxoid chondrosarcoma | t(9;22)(q22-23;q11-12) t(9;15)(q22;q21) t(9;17)(q22;q11) |
EWS-TEC (CHN)
TCF12-TEC TAF2N-TEC |
| Extraskeletal mesenchymal chondrosarcoma | der(13;21)(q10;q10) | NA |
| 2B. Non-rhabdomyosarcoma–others | ||
| Synovial sarcoma | t(X;18)(p11;q11) |
SYT-SSX1
SYT-SSX2 |
| Inflammatory myofibroblastic tumor | t(1;2)(q25;p23) t(2;19)(p23;p13) |
TPM3-ALK
TPM4-ALK |
| Myxoid/round cell liposarcoma | t(12;16)(q13;p11) t(12;22)(q13;q12) |
TLS-CHOP
EWS-CHOP |
| Alveolar soft part sarcoma | t(X;17)(p11;q25) | ASPL- TFE3 |
N/A, not applicable/not know
Modified from reference 55.