Fig. 6. Forsythiaside inhibited the implant-associated osteolysis in vivo. Ti implant (1.5 mm × 10 mm) was implanted into the femoral condyle, and then, Ti particles were injected into the tissue around the implant. After that, forsythiaside or PBS was injected every alternate day for 14 days. At the end, all mice were sacrificed, and the femurs were excised. (A) Representative micro-CT 3D reconstructed images were obtained for each group. (B). Quantitative analysis results from micro-CT evaluation. BV/TV = the bone volume/total volume; Tb.Th = the mean trabecular thickness; Tb.sp = trabecular spacing; Tb.N = trabecular number *P < 0.05.