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. 2022 May 3;23(3):393–408. doi: 10.1007/s40257-022-00685-0

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Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 4 — Mean weekly Pruritus NRS score over time. *Uptick because of patient re-entry to the study at week 156. BL baseline, LOCF last observation carried forward, NRS Numerical Rating Scale, OC observed cohort, PSBL parent study baseline, SE standard error