Table 3.
Duration of dupilumab exposure by dose in patients who switched from qw to q2wa
| Patients with treatment exposure, weeks | Dupilumab dose (N = 226) | ||
|---|---|---|---|
| Overall exposure (300 mg qw or q2w) | 300 mg qw | 300 mg q2w | |
| 1 to <4 | 0 | 0 | 0 |
| 4 to <12 | 0 | 0 | 1 (0.4) |
| 12 to <16 | 0 | 0 | 1 (0.4) |
| 16 to <24 | 0 | 0 | 2 (0.9) |
| 24 to <52 | 0 | 0 | 175 (77.4) |
| 52 to <76 | 0 | 0 | 47 (20.8) |
| 76 to <156 | 0 | 0 | 0 |
| 156 to <182 | 0 | 67 (29.6) | 0 |
| 182 to <208 | 5 (2.2) | 99 (43.8) | 0 |
| 208 to <234 | 70 (31.0) | 56 (24.8) | 0 |
| 234 to <260 | 112 (49.6) | 4 (1.8) | 0 |
| ≥260 | 39 (17.3) | 0 | 0 |
Data are expressed as n (%) unless otherwise specified
q2w every 2 weeks, qw weekly
aPatients transitioned from dupilumab qw to q2w following Protocol Amendment 9