Effect sizes for family history and polygenic risk scores
	Family history	Family history adjusted with PRS	PRS	PRS adjusted with family history
	OR (95% CI)	OR (95% CI)	OR per SD (95% CI)	OR per SD (95% CI)
Breast cancer	2.46 (2.01-3.00)	2.06 (1.68-2.54)	1.76 (1.63-1.91)	1.71 (1.58-1.85)
Venous thromboemolism	1.80 (1.46-2.21)	1.70 (1.38-2.09)	1.40 (1.32-1.48)	1.39 (1.31-1.47)
Glaucoma	2.50 (2.05-3.06)	2.25 (1.84-2.76)	1.64 (1.53-1.77)	1.61 (1.50-1.74)