Clinical phenotype comparisons between our patient and the previous cases with gain of one copy at band 14q22q23.1 that include OTX2 gene
	Our patient	Ballesta-Martínez MJ, 2013PMID: 23794319						Zielinski D, 2014PMID: 24816892					Ehrenberg M,2019PMID: 31814694
Family relationship	Index case	Index case	Father	Uncle	Cousin	Cousin´s son	Cousin´s daughter	Maternal grand-mother	Maternal great-uncle	Mother	Brother	index case	Indexcase	Father
Facial asymmetry	+	+	+	-	-	+	+	+	+	+	+	+	+	+
Facial cleft	-	+	+	-	-	+	-	+	+	+	+	+	-	ND
Temporo-mandibular joint abnormality	+	+	-	-	ND	ND	ND	+	+	+	+	+	-	ND
Ear constriction/cleft/microtia	+	+	-	-	-	+	+	-	-	-	-	+	+	ND
Auricular pits	-	+	-	-	-	+	+	ND	ND	ND	ND	ND	-	ND
Pre- or post-auricular tags	+	+	+	+	+	+	+	+	-	+	+	+	-	ND
Stenoticnarrow ear canals	+	+	-	ND	ND	+	+	ND	ND	ND	ND	ND	-	ND
Abnormal palate	-	-	-	-	-	-	-	ND	ND	ND	ND	ND	-	ND
Micrognathia	+	+	-	-	-	-	-	-	+	-	+	+	+	ND
Hearing loss	+	+	-	-	ND	-	-	ND	ND	ND	ND	ND	+	ND