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. 2022 Apr 19;13:882198. doi: 10.3389/fphar.2022.882198

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Copyright © 2022 Liu, Zhao, Zhu, Wang, Liu, Nie, Zhao, Wang and Cheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of rhynchophylline on the degree of apoptosis in cardiac tissue. (A) Representative sections of apoptosis in cardiac tissues of each group (magnification, ×200). (B) The degree of apoptosis in cardiac tissue. (C–H) Caspase-3, Bax, and Bcl-2 protein expressions in heart tissue were determined by western blot analysis. Relative intensities of caspase-3 (D), Bax (F), and Bcl-2 (H) were calculated by normalization to glyceraldehyde-3-phosphate dehydrogenase in each group; Values are presented as mean ± standard error of the mean. *p < 0.05, **p < 0.01 vs. control group; #p < 0.05, ##p < 0.01 vs. type 2 diabetes mellitus group (n = 3, 1-way analysis of variance, Holm–Sidak post-hoc test).