Table 2.

CHIP is associated with CKD complications

Outcome	Cohort	CHIP (univariable)		CHIP (adjusted for age, sex, and baseline eGFR)
		β±SEM	P	β±SEM	P
log(ACR [mg/g])	Kingston	0.12±0.51	0.82	0.59±0.50	0.24
	CanPREDDICT	−0.05±0.45	0.91	0.13±0.45	0.78
	Pooled	−0.02±0.34	0.95	0.31±0.33	0.35
Hemoglobin (g/dl)	Kingston	−1.62±0.42a	<0.001	−1.38±0.39a	<0.001
	CanPREDDICT	−0.67±0.39	0.09	−0.64±0.40	0.113
	Pooled	−1.12±0.29a	<0.001	−0.95±0.28a	<0.001
Urea (mmol/L)	Kingston	4.3±1.9a	0.02	2.8±1.4	0.05
	CanPREDDICT	0.7±1.7	0.70	−0.7±1.3	0.61
	Pooled	2.5±1.2	0.05	0.8±1.0	0.40
Bicarbonate (mEq/L)	Kingston	−2.4±0.7a	0.002	−2.0±0.7a	0.005
	CanPREDDICT	−0.3±0.9	0.74	−0.1±1.0	0.93
	Pooled	−1.4±0.6a	0.02	−1.0±0.57	0.10
PTHa (pg/ml)	Kingston	8.6±2.9a	0.004	7.2±2.6a	0.007
	CanPREDDICT	9.2±6.3	0.15	8.8±5.9	0.14
	Pooled	8.9±2.7a	0.002	6.9±2.5a	0.006
Phosphate (mmol/L)	Kingston	0.16±0.07a	0.02	0.13±0.06	0.05
	CanPREDDICT	0.05±0.05	0.35	0.04±0.05	0.38
	Pooled	0.09±0.04a	0.03	0.08±0.04	0.06
Calcium (mmol/L)	Kingston	−0.04±0.03	0.23	−0.04±0.03	0.27
	CanPREDDICT	−0.01±0.03	0.73	−0.01±0.03	0.69
	Pooled	−0.03±0.02	0.25	−0.02±0.02	0.29
MCV (fl)	Kingston	2.6±1.2a	0.03	1.8±1.2	0.14
Ferritin (µg/L)	Kingston	135.6±37.9a	<0.001	128.2±38.2a	0.001
Transferrin saturation (%)	Kingston	1.9±2.8	0.50	2.9±2.9	0.32
log(CRP)	Kingston	0.1±0.33	0.77	0.05±0.34	0.89
	CanPREDDICT	0.1±0.28	0.77	−0.02±0.29	0.94
	Pooled	0.1±0.21	0.67	−0.03±0.22	0.88
log(FGF23)	Kingston	0.11±0.26	0.66	−0.06±0.21	0.78
	CanPREDDICT	−0.09±0.16	0.57	−0.17±0.12	0.16
	Pooled	0.05±0.15	0.73	−0.15±0.13	0.26

The results of univariable (CHIP) and multivariable (CHIP, age, sex, baseline eGFR) linear regressions are presented for each secondary outcome of interest. The β coefficient indicates the quantitative change in the outcome for those with CHIP compared with those without CHIP.

^aPTH values excluded two individuals who had primary hyperthyroidism (one individual with CHIP who was untreated at baseline and one without CHIP who had received parathyroidectomy before baseline assessment).