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. 2022 May;33(5):1011–1032. doi: 10.1681/ASN.2021101327

Table 4.

Summary of vitamin D study characteristics and VC outcome

Author and Year Type of Study Study Duration (months) Participant Intervention (Participants at Baseline) Comparator (Participants at Baseline) VC as Primary or Secondary End Point VC Imaging VC Site VC Outcome
Baker 198657 RCT 60 HD Calcitriol, n=38 Placebo, n=38 Secondary X-ray Hands, feet, pelvis, coronary artery No significant VC attenuation at all sites
Morosetti 200858 Non-RCT 24 HD High-dose calcitriol, n=18 Low-dose calcitriol + sevelamer, n=18 Primary CT Coronary artery No significant VC attenuation
Delanaye 201359 RCT 12 HD, serum 25(OH)D <30 ng/ml Cholecalciferol, n=22 Placebo, n=21 Secondary X-ray lateral Abdominal aorta No significant VC attenuation
Kidir 201560 Non-RCT 6 HD or PD Cholecalciferol, n=26 Standard treatment, n=17 Primary X-ray hand & pelvis Radial arteries, digital arteries, iliac arteries, femoral arteries No significant VC attenuation at all sites
Samaan 201961 RCT 18 CKD stage 3–4, serum 25(OH)D <30 ng/ml Cholecalciferol, n=23 Placebo, n=24 Primary CT Coronary artery No significant VC attenuation
Anis 202062 RCT 11 (48 weeks) CKD stage 3–4 with SHPT Calcitriol, n=22 Paricalcitol, n=22 Primary CT Coronary artery, aortic valve, mitral valve No significant VC attenuation at all sites

HD, hemodialysis; PD, peritoneal dialysis.