Table 8.
Summary of sodium thiosulfate study characteristics and VC outcome
| Author and Year | Type of Study | Study Duration (months) | CKD Status | Intervention (Participants at Baseline) | Comparator (Participants at Baseline) | VC as Primary or Secondary End Point | VC Imaging | VC Site | VC Outcome |
|---|---|---|---|---|---|---|---|---|---|
| Adirekkiat 201082 | Non-RCT | 4 | HD | STS post-HD twice weekly, n=16 | Dialysis as usual, n=16 | Primary | CT | Coronary artery | Less progression with STS |
| Mathews 201183 | Non-RCT | 5 | HD | STS post-HD three times per week, n=22 | No control group | Primary | CT | Carotid artery, coronary artery, thoracic arch | Less progression with STS |
| Yonova 201484 | Non-RCT | 6 | HD | STS intradialytic, n=6 | Controls, n=6 | Primary | CT | Coronary artery | Less progression with STS |
| Yu 201685 | RCT | 3 | HD | STS post-HD + calcium carbonate, n=15 | Calcium carbonate, n=10 | Primary | CT | Coronary artery | Less progression with STS |
| Saengpanit 201886 | RCT | 6 | HD | STS intradialytic twice weekly, n=24 | Standard of care, n=26 | Secondary | CT | Coronary artery | Less progression with STS |
| Djuric 202087 | RCT | 6 | HD | STS post-HD, n=30 | 0.9% NaCl during dialysis, n=30 | Primary: abdominal aorta, secondary: iliac | CT | Abdominal aorta, iliac arteries, cardiac valves | Less progression with STS at iliac arteries |
| Bian 202188 | RCT | 6 | HD | STS, n=25 | Usual treatment, n=25 | Primary | CT | Coronary artery | Less progression with STS |
HD, hemodialysis; STS, sodium thiosulfate.