Table 2.
Pathologic findings in FAT1-associated MN
| Patient Number | Number of Glomeruli | Number of Sclerosed Glomeruli | Interstitial Fibrosis and Tubular Atrophy (%) | IF Microscopy | TBM Deposits | EM Stage |
|---|---|---|---|---|---|---|
| 1 | 17 | 2 | 20 | IgG 3+, C3 1+, IgG4 3+ | No | I |
| 2 | 17 | 6 | 20 | IgG 3+, C3 1+ | Yes | II |
| 3 | 43 | 18 | 60 | IgG 3+, C3 1+, IgG4 3+ | Yes | II |
| 4 | 86 | 68 | 80 | IgG 3+, C3 1+ | Yes | II |
| 5 | 36 | 4 | 20 | IgG 3+ | No | II |
| 6 | 6 | 1 | 20 | IgG 3+, C3 1+ | No | II |
| 7 | 57 | 2 | 5 | IgG 3+, C3 1+, IgG4 3+, IgG2 2+ | No | II |
| 8 | 50 | 9 | 5 | IgG 2+, C3 1+ | No | II |
| 9 | 55 | 2 | 10 | IgG 2+, IgG4 2+ | No | II |
| 10 | 41 | 2 | 10 | IgG 3+, C3 1+, IgG4 3+ | No | II |
| 11 | 18 | 1 | 10 | IgG 2+, C3 1+, IgG4 3+ | No | II |
| 12 | 16 | 0 | 10 | IgG 2+ | No | I |
| 13 | 7 | 0 | 20 | IgG 1–2+, C3 1+ | No | I |
| 14 | 16 | 4 | 20 | IgG 3+, C3 1+ | No | I |
Mayo Clinic cohort patients 1–5 and 11–14; Cedars Sinai cohort patients 6–10. EM, electron microscopy.