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Inhibitory effects of quinolones against type II topoisomerases
| Compound | IC50 (μg/ml) for:
|
|||
|---|---|---|---|---|
| DNA gyrase
|
Topoisomerase IV
|
|||
| Wild type | T83I | Wild type | S87L | |
| Levofloxacin | 0.88 | 10.4 | 4.96 | 49.2 |
| Sitafloxacin | 0.42 | 1.85 | 2.12 | 8.62 |
| Ciprofloxacin | 0.55 | 8.29 | 4.06 | 33.0 |
| Sparfloxacin | 0.75 | 17.5 | 6.14 | 52.3 |
