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. Author manuscript; available in PMC: 2022 May 3.
Published in final edited form as: J Med Chem. 2020 Oct 6;63(20):11934–11944. doi: 10.1021/acs.jmedchem.0c01198

Scheme 1: General Route for the Synthesis of trifluoromethylthio-containing N-(1,3,4-oxadiazol-2-yl)benzamidesa.

Scheme 1:

aReagents and Conditions: (a) Semicarbazide hydrochloride, NaOAc, MeOH:H2O (1:1), rt, 30 min, 95% (b) Bromine, NaOAc, AcOH, 60 °C, 1 h, 40% – 70% (c) BOP Reagent, DIPEA, DMF, rt, 12 h, 16% – 33%.