Table 3.
MICs in μg/mL (μM) of HSGN-218 and control antibiotics against vancomycin-resistant enterococci (VRE) and Escherichia coli isolates.
| Compound/Control Antibiotic | E. faecium ATCC 700221 | E. faecalis ATCC 51299 | E. coli JW55031 (TolC Mutant | E. coli BW25113 (wild-type strain) |
|---|---|---|---|---|
| HSGN-218 | 0.125 (0.29) | 0.06 (0.14) | 4 (9.2) | >16 (>36.8) |
| Vancomycin | 32 (22.1) | >64 (>44.2) | >64 (>44.2) | >64 (>44.2) |
| Metronidazole | >64 (>373.9) | >64 (>373.9) | NT1 | NT |
| Linezolid | 1 (3.0) | 1 (3.0) | 16 (47.4) | >64 (>189,7) |
| Gentamicin | NT | NT | 0.25 (0.52) | 0.25 (0.52) |
NT1, not tested