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. Author manuscript; available in PMC: 2022 May 3.
Published in final edited form as: J Med Chem. 2020 Oct 6;63(20):11934–11944. doi: 10.1021/acs.jmedchem.0c01198

Table 4.

Caco-2 Permeability Analysis for HSGN-218 and Control Drugs.

Compound/Control Drug Mean A → B Papp (cm s−1) Mean B → A Papp (cm s−1) Notes
HSGN-218 0.2 × 10−6 0.1 × 10−6 Low Permeability
Ranitidine 0.5 × 10−6 1.3 × 10−6 Low Permeability Control
Propranolol 37.2 × 10−6 22.7 × 10−6 High Permeability Control