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. Author manuscript; available in PMC: 2022 May 3.
Published in final edited form as: J Med Chem. 2020 Oct 6;63(20):11934–11944. doi: 10.1021/acs.jmedchem.0c01198

Table 5.

MICs in μg/mL (μM) of HSGN-218 and control antibiotics against human normal gut microbiota.

Bacterial strains HSGN-218 Vancomycin Metronidazole Fidaxomicin
Lactobacillus gasseri HM-400 16 (36.8) ≤1 (≤0.7) >64 (>373.9) >64 (>60.5)
Lactobacillus crispatus HM-103 16 (36.8) 2 (1.4) >64 (>373.9) >64 (>60.5)
Lactobacillus crispatus HM-371 16 (36.8) 2 (1.4) >64 (>373.9) >64 (>60.5)
Bacteroides fragilis HM-711 2 (4.6) 64 (44.2) ≤1 (5.84) >64 (>60.5)
Bacteroides fragilis HM-709 1 (2.3) 32 (22.1) 2 (11.68) >64 (>60.5)
Bacteroides dorei HM-719 2 (4.6) 64 (44.2) ≤1 (5.84) >64 (>60.5)