Table 5a.
Multivariate analysis of outcomes for t-MDS.
| Outcomes | N | HR (95% CI) | p-value |
|---|---|---|---|
| Non-Relapse Mortality | |||
| Type of donor | 0.03 | ||
| HLA-identical sibling | 212 | Reference | |
| Well-matched unrelated (8/8) | 373 | 1.06 (0.78–1.44) | 0.73 |
| Partially-matched unrelated (7/8) | 88 | 1.28 (0.84–1.96) | 0.25 |
| Mis-matched unrelated (<=6/8) | 11 | 2.80 (1.21–6.49) | 0.02 |
| Unrelated (matching unknown) | 8 | 3.12 (1.13–8.59) | 0.03 |
| Cord blood | 50 | 1.51 (0.91–2.50) | 0.11 |
| Relapse | |||
| Age | < 0.001 | ||
| 18–60 | 424 | Reference | |
| 60+ | 318 | 1.56 (1.25–1.94) | < 0.001 |
| Prior auto-HCT | < 0.001 | ||
| No | 564 | Reference | |
| Yes | 178 | 1.58 (1.25–2.01) | < 0.001 |
| IPSS-R | < 0.001 | ||
| Low/very low | 136 | Reference | |
| Intermediate | 171 | 1.04 (0.73–1.49) | 0.83 |
| High | 165 | 1.20 (0.85–1.70) | 0.30 |
| Very high | 122 | 1.98 (1.39–2.81) | < 0.001 |
| Missing | 148 | 1.08 (0.75–1.56) | 0.67 |
| Disease-Free Survival | |||
| Age | < 0.001 | ||
| 18–60 | 424 | Reference | |
| 60+ | 318 | 1.41 (1.20–1.67) | < 0.001 |
| Prior auto-HCT | 0.010 | ||
| No | 564 | Reference | |
| Yes | 178 | 1.28 (1.06–1.54) | 0.010 |
| IPSS-R | 0.003 | ||
| Low/very low | 136 | Reference | |
| Intermediate | 171 | 1.24 (0.96–1.60) | 0.10 |
| High | 165 | 1.12 (0.86–1.46) | 0.39 |
| Very high | 122 | 1.66 (1.26–2.19) | < 0.001 |
| Missing | 148 | 1.12 (0.85–1.47) | 0.41 |
| Overall Survival | |||
| Age | 0.001 | ||
| 18–60 | 435 | Reference | |
| 60+ | 324 | 1.33 (1.12–1.59) | 0.001 |
| Type of donor | 0.002 | ||
| HLA-identical sibling | 214 | Reference | |
| Well-matched unrelated (8/8) | 383 | 0.98 (0.80–1.21) | 0.88 |
| Partially-matched unrelated (7/8) | 90 | 1.13 (0.84–1.52) | 0.44 |
| Mis-matched unrelated (<=6/8) | 12 | 2.78 (1.53–5.07) | < 0.001 |
| Unrelated (matching unknown) | 8 | 2.41 (1.12–5.20) | 0.02 |
| Cord blood | 52 | 1.24 (0.86–1.78) | 0.25 |
| IPSS-R | < 0.001 | ||
| Low/very low | 138 | Reference | |
| Intermediate | 176 | 1.32 (1.00–1.74) | 0.05 |
| High | 166 | 1.17 (0.88–1.56) | 0.27 |
| Very high | 125 | 1.81 (1.35–2.41) | < 0.001 |
| Missing | 154 | 1.17 (0.88–1.56) | 0.28 |
t-MDS, treatment related myelodysplasia; CI, confidence interval; Prob, probability; N, number; MAC, myeloablative conditioning; RIC, reduced intensity conditioning; NMA, non-myeloablative conditioning.